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Treatment of alopecia areata with dinitrochlorobenzene.
Daman LA, et al

Persistent refractory hair loss due to alopecia areata in 26 patients was treated with DNCB. Sixteen patients have had excellent regrowth of hair; three patients could either not be initially sensitized or an adequate allergic contact dermatitis on the scalp did not develop. Two patients discontinued therapy within two months; hair regrowth did not develop in five patients despite an adequate trial. Augmentation of the T-lymphocyte pool via DNCB sensitization and challenge may become effective therapy for some patients with severe hair loss due to alopecia areata.
]]> General http://qr.st/blog/index.php?itemid=50 Sun, 3 Jan 2010 14:41:13 -0500 http://qr.st/blog/index.php?itemid=49
Hair follicle biology and topical minoxidil
Headington JT.

The mechanism by which minoxidil stimulates hair growth remains undetermined. Possible indirect drug action, such as vasodilatation and increased blood flow to the dermal papilla, or possible local irritation related to minoxidil or to one or more components of the vehicle used for topical application has been suggested. Possible sites of direct drug action include either the dermal papilla of the follicle or hair matrix cells or possibly both. Because the dermal papilla of the hair follicle apparently controls both growth and differentiation of hair matrix cells and because there are no observable dysplastic or atypical changes in follicular germinal epithelium during or after application of topical minoxidil, it is concluded that the most probable site for the action of minoxidil is on the specialized mesenchymal cells of the follicular dermal papilla.
]]> General http://qr.st/blog/index.php?itemid=49 Sun, 15 Nov 2009 12:43:26 -0500 http://qr.st/blog/index.php?itemid=48 Hormonal diagnosis in so-called androgenetic alopecia (pattern hair loss) in the female
Moltz L.
edited for blog...
Androgenetic alopecia (a.A.) or pattern hair loss occurs quite frequently. Up to 79% of women suffer at least temporarily from varying degrees of intermittent diffuse hair loss. A.A. is caused by an androgen excess acting on the hair follicle for prolonged periods of time in the presence of a genetic predisposition. However, often hyperandrogenemia cannot be demonstrated in such patients. 125 women with clinically typical a.A. were investigated prospectively under standardized conditions. ..snip... Therapy was directed at normalizing the disturbed estrogen-androgen-balance. Using low-dose antiandrogens, estrogens, prolactin suppressants, corticoids, iron-II-preparations as well as estrogen-containing hair lotions hair loss was arrested in 74 of 104 treated women, while regrowth of hair was accomplished in 16 patients. 14 women did not respond to treatment.
]]> General http://qr.st/blog/index.php?itemid=48 Tue, 10 Nov 2009 17:43:31 -0500 http://qr.st/blog/index.php?itemid=47
Abnormal expression of class I and class II major histocompatibility antigens in hair loss due to alopecia areata
Bröcker EB, et al

Fifty-eight scalp biopsies were immunohistologically investigated with monoclonal antibodies against HLA-ABC, HLA-DR, and T6 antigens. The following 3 groups were compared: control biopsies obtained from healthy volunteers (n = 5) or patients with unrelated scalp diseases (n = 6); biopsies from untreated hair loss due to alopecia areata..... snip.. By contrast, 30 out of 32 biopsies from untreated AA showed expression of HLA-ABC antigens on hair matrix epithelium, and the subinfundibular epithelium was HLA-ABC-positive in 15 out of 32 cases. In the biopsies from treated AA, HLA-ABC antigens were expressed on hair matrix epithelium in 9 out of 13 cases, and on the subinfundibular epithelium in 1 case. In the controls and untreated AA, HLA-DR expression was confined to dendritic cells in the epidermis and the follicular infundibulum. Its expression on hair matrix epithelium was found in 15 out of 32 biopsies from untreated AA and in 4 out of 13 biopsies from treated AA. In the control series, intrabulbar T6+ dendritic cells were either absent or present in low numbers. High numbers of intrabulbar T6+ cells were present in 7 out of 32 biopsies from untreated AA and in 0 out of 13 biopsies from treated AA. et al]]> General http://qr.st/blog/index.php?itemid=47 Tue, 3 Nov 2009 22:48:49 -0500 http://qr.st/blog/index.php?itemid=46 Dr Proctor Treats Hair Loss


Hair loss blogspot]]> General http://qr.st/blog/index.php?itemid=46 Thu, 29 Oct 2009 16:03:15 -0400 http://qr.st/blog/index.php?itemid=45 Follicular mucinosis in alopecia areata.

Fanti PA,et al

edited for use in this hair loss blog

The features of hair loss secondary to alopecia areata were described. ..snip.. The abundance of helper/inducer cells along with the involvement of the upper part of the hair follicles might explain the development of follicular mucinosis in this case. Different possibilities were discussed, but the clinical presentation and the follow-up favored the clinical and pathological interpretation of alopecia areata with incidental findings of follicular mucinosis.

]]> General http://qr.st/blog/index.php?itemid=45 Mon, 26 Oct 2009 22:52:48 -0400 http://qr.st/blog/index.php?itemid=44 Minoxidil may induce hair regrowth in alopecia areata by a synergistic stimulatory effect on follicular epithelium and a suppressive effect on lymphocyte-mediated immunologic phenomena. A contributing role for its vasodilatory properties must also be considered.

]]> General http://qr.st/blog/index.php?itemid=44 Sat, 24 Oct 2009 19:43:16 -0400 http://qr.st/blog/index.php?itemid=43
Alopecia areata: alterations in the hair growth cycle and correlation with the follicular pathology.

Messenger AG, et al

A histopathological study was performed in 17 patients with hair loss due to alopecia areata to elucidate the changes in hair cycle dynamics. The findings confirm the view that the initial event in alopecia areata is the premature entry of anagen follicles into telogen, although some follicles survive for a time in a dystrophic anagen state. However, after re-entry into anagen takes place, growth appears to be halted in anagen III rather than anagen IV, as has previously been suggested. Follicles then return prematurely to telogen and these truncated cycles are repeated until the disease activity subsides. A new pathogenic hypothesis is presented which relates alterations in hair cycle dynamics to pathological changes within the anagen follicle and also provides an explanation for the formation of exclamation mark hairs and the non-destructive nature of the disease.

]]> General http://qr.st/blog/index.php?itemid=43 Fri, 23 Oct 2009 20:26:00 -0400 http://qr.st/blog/index.php?itemid=42
Immunofluorescence findings in rapid whitening of scalp hair

Guin J et al

Rapid whitening of scalp hair developed during a three-month period along with a diffuse, subtotal alopecia (hair loss) in a patient. Immunofluorescence microscopy of biopsy material showed prominent deposits of IgG and IgM in a granular pattern in the epithelium of the lower portions of hair follicles. Some return of the color and amount of scalp hair occurred within a year, but occasional bouts of hair loss continued to occur. It is theorized that the rapid graying was caused by a selective loss of pigmented hair, which was perhaps caused by an immunologic mechanism. Some of the findings suggest that the cause of this patient's loss of hair color may be different from those of patients who have been previously described as having rapid whitening of scalp hair because of alopecia areata or vitiligo.

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]]> General http://qr.st/blog/index.php?itemid=42 Wed, 21 Oct 2009 11:41:49 -0400 http://qr.st/blog/index.php?itemid=41
Experimental studies on seborheric alopecia (male pattern hair loss). III. Localization of testosterone receptors in human hairy follicles

Bassas E.

The author studies the location of the testosterone receptors in huamn hair follicles, by means of the isolation of the two most outstanding fractions of the pilosebaceous follicle, i.e., hair follicle and sebaceous gland. The two fractions were obtained by micro-dissection, homogenisation by separate, and isolation of the correspondig cytosol fraction. It was demonstrated that the two fractions possess the same binding activity against the androgen tested
]]> General http://qr.st/blog/index.php?itemid=41 Tue, 20 Oct 2009 17:17:31 -0400